SRA (Temporary Position) - Protein Characterization

Company: Tentarix
Location: San Diego
Posted on: May 29, 2025

Job Description:

About the Company:Tentarix Biotherapeutics is a biotechnology company with a revolutionary platform for the discovery of next generation, multispecific biologic drugs, with the potential to make a significant difference in the lives of patients suffering with diseases, such as cancer and autoimmunity.We are led by a seasoned executive team with proven expertise in the field of multispecific drug discovery, drug development, and company-building. We are supported by top tier healthcare investors and have several ongoing partnered programs with Gilead and AbbVie.We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape.The Tentarix culture is founded on integrity, accountability, teamwork, and respect. Our team members are creative, hands-on, self-directed, and determined. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our team.Temporary Role:The Senior Research Associate will contribute to laboratory-based protein science efforts at Tentarix, focusing on the purification and biophysical and biochemical characterization of recombinant proteins to support preclinical research.Responsibilities:

• Primarily responsible for performing protein characterization and developability assessment for lead identification and optimization.
• Protein characterization, including conformational, colloidal, and chemical stability, as well as other biophysical attributes, using UPLC/HPLC, BLI, Nanotemper, Mass spectrometry, and other methodologies.
• High throughput small-scale batch purifications, and large-scale, FPLC-based protein purification using affinity, ion exchange, and size exclusion chromatography.
• Support epitope binning and mapping.
• Independently plan and execute experiments, analyze results, and present data at team meetings.
• Maintain a meticulous record of their research.Qualifications and Skills:
  • B.S., plus 4 or more years or M.S plus 2 or more years of industry experience with recombinant protein purification and characterization.
  • Prior experience with antibody and soluble protein affinity chromatography techniques as well as experience choosing secondary purification methodologies.
  • Experience examining various aspects of protein stability by UPLC/HPLC and thermal stability, is highly desired.
  • Experience with protein characterization by mass spectrometry is a plus.
  • Goal-oriented, highly organized, and capable of multitasking.
  • Strong communication and record-keeping abilities.
  • Thrive in a cross-functional team environment.The wage range for this role takes into account the wide range of factors that are considered in making compensation decisions including, but not limited to, skill sets, experience, training, licensure, certifications, and other business and organizational needs. The disclosed range estimate has not been adjusted for the applicable geographic differential associated with the location at which the position may be filled. At Tentarix, it is not typical for an individual to be hired at or near the top of the range for their role and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate for this temporary role is a range of $50 - $65 per hour, depending on experience.Our employees are the Company's most valuable assets, so we offer attractive compensation and benefits packages to retain the best in the field. Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.Applicants must be currently authorized to work in the United States on a full-time basis.Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.We are an E-Verify employer.
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Keywords: Tentarix, Placentia , SRA (Temporary Position) - Protein Characterization, Other , San Diego, California